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Fortune 500: Missouri is Home to Eight Top Businesses
Eight Missouri-based companies were included in the 2025 Fortune 500 list, which is based on fiscal year 2024 revenue. Centene is the highest ranked Missouri company among Fortune 500 companies. The company dropped from 22nd in the rankings in 2024 to 23rd in 2025 but had a year-over-year revenue increase of 5.9 percent to reach $163 billion. Seven of Missouri’s Fortune 500 companies are in the St. Louis area, while one is in Springfield.

Missouri 2025 Annual Exports
Exports from Missouri to other countries decreased 3.5 percent from 2024 to 2025, totaling just under $18.68 billion. More than half of Missouri’s export income is to countries in North America. Canada purchased $5.8 billion in goods, led by the export industry of motor vehicles. Mexico ($4.3 billion) was the second largest, led by oilseeds and grains.